I was shooting in the 1900 to 2000 fps range and intend to stay in the same zone. I'm under the impression that less than 2200 fps makes things significantly easier to get dialed in and figure out.
The first cast rifle bullets I loaded over 2000fps was for my .348WCF... a 200grn Montana Bullet FN/GC bullet over IMR3031. I had it tooling along around 2300fps. I lucked out... it was the perfect bullet for my rifle, sized at .349"... although I would have gone to .350" if they would have had them available.
The .308's were a different story, however. In my Savage 99 .308, a generic 173grn .309" commercial cast (LaserCast...) worked well enough, loaded to 1800fps. Again, I lucked out... if not the perfect bullet, at least an adequate bullet. Moving past 2000fps in the 99, I had to go to the Montana 173grn GC bullet to get the triumvirate of velocity, accuracy, and no leading... I don't know if that was due to bullet material, the gas check, bullet cast quality... or any combination.
When I got my Savage 99 in .30-30... things strayed a little. The same .309" LaserCast bullet produced horrible accuracy. Switching to the Montana, I was surprised to find they did, too, even with velocity ranges of 1400-1800fps. A quick order to Montana for the same bullet, but in .310", proved to be the correct combination... for that rifle.
Once you get your mold, and start dropping bullets worthy of loading... I would start with a target velocity of 1600-1700fps... easy enough with IMR4227. Work your way up to the velocity you want to achieve... looking for signs of deteriorating accuracy, and/or things like barrel leading. I'm more likely to say you will start seeing issues at 2000fps, rather than 2200fps... just my experience. Don't discount powders like IMR4198 or even IMR3031, but their starting velocities will be higher, normally.