Different functions.
(Aside to Skunkabilly: Son, come here. I keep telling you, you HAVE to take your medication. Seriously.)
The 45 ACP shines as a defensive round, and the 357 Magnum shines as a general purpose round. I feel comfortable with either.
The Model 25 is a perfect revolver in 45 ACP. I believe Grizzly or Desert Eagle made a 357 Magnum semi-auto. But the fact is, the 1911 is where the soul of the 45 stays, and S&W revolver is another way of saying 357 Magnum. (Or 44....)
Why am I choosing? I've got both!