Went shooting with my oldest daughter & son-in-law today. My oldest daughter likes shooting 22s. She tried my Model 60LS with Pachmayr Compact rubber grip (357 & 38), and my son-in-law's SP101 & 686+ (38 ammo).
Her shooting was OK with any combo. However, she didn't like the 60LS even with regular 38 ammo - more kick than she wanted. The SP101 felt good for recoil, but she didn't like the weight of the trigger pull. She enjoyed shooting the 686+ (3") with 38 or 38+P, and was surprised at how much the weight reduced the recoil.
She now is trying to decide if she is willing to carry the weight of the 686+ (37 oz) or not. If not, she'll carry a 22. The 38+P is obviously way better than .22 as a defensive round, but I don't believe in carrying any gun you aren't willing to first go shoot 200+ times. And since she enjoys shooting 22s out of a semiauto, that may end up being her decision. From my perspective, 10 rounds of 22 that you KNOW how to shoot are better than her having my 6-shot 44 mag Ruger Alaskan. The only time I pulled a gun, it was a 22 revolver, and the other guys didn't laugh at it for being a 22. I left without firing a shot, and joined the ranks that day of those who had deterred a crime without actually shooting anyone.
I'll add that my carry gun is a 686+, 3" barrel using .357 ammo. It is the biggest gun I'm willing to carry, and it is very comfortable for me to shoot with 357. It is the kind of gun that makes my wife shake her head at the cost of ammo...because that is what limits how much I shoot it!