They're probably not as hot as you think. The DW's are stout guns, so I don't think you'll hurt anything.
I shot a lot of Keith style #429421's back in the late '70's through a M29 over 22.0-23.0gr of #2400. Didn't hurt me or the gun. Although, todays #2400 is said to be a bit faster burning, all the old data I've tried comes up pretty close to what I saw 30yrs ago. Then again, it's mostly been through rifles with cast bullets and a Ruger Redhawk in .45Colt.
Only thing is, the gun I've got now is a 329PD. With any of the "old" loads, it'll just walk the bullets out the front of the cylinder and tie up everything till the bullets are punched back into the cylinders. S&W found an interesting way to make me back down the .44 loads....... Even with the bullets crimped as much as I can without distorting the bullets, the full power loads will just walk out of the cylinders in 3 or 4 shots. Only solution is to only load 2 rounds in the gun at a time till I shot them all up. (lubed with SPG, so pulled bullets and powder are a gummy mess....)
It took only a few of the 255gr Keiths over 22.0gr of H110 (w/CCI#350's) to make me realize that I'm too old, and the arthritis too bad in my thumbs to shoot any more of those. 5.9gr of Clays and a 200gr RFN is just enough now , thankyou !!! I'll leave the #2400 for "heavier" guns.....