Again, the need to define purpose - - -
Hunting or personal defense?
G45LE "Gold Dot" 45 Long Colt 200 Gr Hollow Point (New Ammunition) 50 Rds FPS: 1100 sounds as if it would be a very good personal defense load - - A BIT better than the warmish .45 ACP loads in same weight.
My personal feeling, though, is that if I'm to carry the somewhat heavier, thicker .45 Colt revolver, I want something more in line with its capabilities. The 250 at 900 comes close to this, without overstressing the S&W DA revolvers.
The 250 GDHP sounds like a good thing, and I'll probably get some for the times when I I take a notion to pack my Mountain Gun on duty - - We're limited to factory loads. I'm sure it would make a nice whitetail deer load, as well. I can't get away from the idea that almost any place in the eastern half of Texas, you're quite apt to run into feral hogs. While I have great respect for the GDHP design, I rather doubt the penetration capability of it, compared to a good semiwadcutter solid. My standard hunting load is a 276 LSWC at around 900. I won't pick a fight with a B'rer Hawg beyond 40 or 50 yards, and the trajectory is plenty flat enough for that distance, and the penetration is excellent . . . .
Best,
Johnny