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I get complete pass throughs on Michigan whitetails shot in the heart/lungs with Cowboy action loads in my 1873. I bought several boxes of this stuff a few years ago so I would have the brass for reloading. My plan was to use a good cast bullet and step it up a little bit which I haven’t done yet.
I think if you keep your shots inside reasonable ranges you would have little trouble taking larger game. Plus your Marlin will handle hotter loads than the 1873. Just my opinion for what it’s worth.