It's kind of interesting that when the British moved from the 455 loads they eventually went to the 380/200 which was a 200 gr. bullet in the 38 S&W cartridge (not the 38 Spl.!) which went about 650 fps or so. They claimed it worked as well as the "Manstopper", at least in shocking power.
One "louisianaman" has well documented the considerable penetrative power of the heavy-bullet .38 S&W: http://castboolits.gunloads.com/showthread.php?t=75914
He has similar threads running on other fora, too.
Cause, I say, for a serious re-consideration of those "anemic" rounds of yesteryear.