There is prevailing empirical wisdom from experienced handgun hunters that momentum or tko figures represent handgun cartridge potential much better than muzzle energy, so it's not too much to conclude the average 480 is more effective over the average 454 unless(!) high speed for those rifle-like distances are the purpose.
But just for fun, forget the head stamp for a minute. Try this approach.
From one end, determine the effects you want to apply to your targets.
First shop for the bullets you'll want to use between .41" and .51". Pick a caliber (not a cartridge) that include good cheap bullets and bullet weights and construction you'll stake your life on, and be able to find both. .41's go up to mid 200's, .429's go up around 300 grains, .451's go up to mid 300's, .475's up to around low 400's, and useful .50-.51's go all the way up into the 500's. Go just big enough to suit your purpose comfortably or your revolver will end up being unnecessarily heavy and with limited options.
Then determine how fast you want to send them. Unless you're going to be shooting at rifle-like distances (~200 yards), just about all of the cartridges can send their relative heavy bullets fast enough for good effects, even the 45 Colt in a strong revolver.
With those loads you want, filter out the cartridges with anything less than very straightforward and safe hand load recipes. And take into account which powders your local stores sell. Search online reloading forums for real world experience with those loads.
Now, transition to the other end, the effects that will apply to your body. Remember that the cartridge name does not determine recoil, especially since you hand load. It's a function of bullet vs gun weight, caliber * pressure product, and barrel length and muzzle dynamics. A 500 Linebaugh can be easier to shoot than a 44 mag or even a 45 colt.
Pick the shooting style (double or single action) you prefer.
Determine the grips that agree best with your hands. A lot of grips are interchangeable.
With all else settled, pick the size of the gun that is the best compromise between shooting comfort and carrying comfort.
Lastly, make sure it gives you an adequate sighting system. Have enough sight radius and/or a good scope mounting option.