64 grain enough for deer?

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As H&H said. Unless you have a custom barrel a 22-250 won't handle bullets that heavy. Most have a 1:14 twist meant to shoot 50 gr and lighter bullets. Most AR's in 223 are twisted 1:9, 1:8, or even 1:7 and will handle 60-80 gr bullets. For that reason most of the time a 223 is a better deer rifle than a 22-250. But if they will shoot accurately in your rifle, they will kill any deer.
 
As has been stated a few times, if the gun will stabilize your bullet you're pretty much good to go with that weight bullet on a deer...especially if it's a bonded bullet, partition type or something a bit more heavily constructed than a varmint round.
 
I have shot Minnesota deer up to 285 lbs with .223 55 gr soft points.they work great. They make mush of the lungs and heart, thin but steady blood trail, very short if any tracking. Like any round it takes a proper expanding bullet that retains integrity and proper placement.
 
The OP has plenty of juice in that round.
Have way too many does around here,and get tags to take em year round due to crop damages. Was popping groundhogs on day with a .17HMR. 9 does stepped out at 85 yards. 6 lived to see the sun set.
1 head shot was bang flop,2 lung/heart shot,farthest on traveled about 30 yards.
A deer is not superman,its a thin skinned animal and hole in the lungs is a dead deer.
 
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