I load for accuracy for my handguns regardless of caliber from the 38 SPL up through my 454. I hunt with them all from time to time, mostly feral hogs but others things as well.
My criteria is a bit more than most I guess and I also go a bit further with my trimming of cases and such. I don't go as far as to weigh them or the bullets for matched batches per say but I do demand a bit more from the end result.
It is simply something I got into the habit of years ago and it works for me. When I load, I usually load in batches of only 50-100, so trimming the cases and such isn't a big deal. If your cases aren;t the same you will never get equal crimps on the bullets which can and does equate to fliers.
I consider a 2" group standing with no rest and a two handed hold at 25yds to be sufficient, but most times will work on things until I can get them smaller. I will test and tweak loads until I get them where I want them and usually will stick with it. Here is one such test, as mentioned above at 25yds with my 454, using the same loads, bullets, and all, but only the lube being different. As you can see the one shot great, while the other simply spread out all over,
I have used this same load to drop an 80'ish pound hog trotting out across my back pasture at 87yds measured with my laser rangefinder. The 310gr cast RFN leaving at just over 1500fps, hit it so hard it literally flipped it over. I cannot ask for anything more, I did my part and the load did the rest. This type of shot isn't the norm, but if I need this sort of performance I expect to be able to use it.
Another couple of groups with my Redhawk in 45 Colt using two different loads and bullet weights, also two handed hold, standing, target at 25yds,
Further testing with both of these loads from this revolver has show these will stay together like this quite nicely out to 50 and 75yds which is about all one can ask for.
Once I can confirm that the loads are good, and consistent, I will start practicing out to 50 and sometimes 100yds, simply to better myself, but to also learn what the loads do. Most of my hunting shots are between 20 and 50yds to be honest, but at times on my farm, and also on my friends property where I do work, the hogs will come out of the woods or brush while we are out working. We do not hesitate to drop the hammer on them if they are within a reasonable range. We have both dropped several nice hogs out to and even past 100yds using our revolvers, but it takes practice and knowing your loads are capable of it.
While I don't have but a couple of auto loaders, the 10mm I have, and the load I use in it are very capable of cleanly dropping a decent sized how out to 50yds and I have used it plenty of times while stalking or when we used to chase hogs with dogs. With my 1911, while I don't consider it to be a hunting sidearm, I wouldn't hesitate to use it up close and personal if I had it on me when slipping through the thick brush where shots can be ranged in feet rather than yards. With some of my cast 200 and up bullets it is not only very accurate but with the RFN designed bullets, it hits hard and penetrates sufficiently for those type encounters. I would not however attempt anything over 20yds with it, as it simply doesn't carry the energy as well as the 10mm with it's 180gr Gold Dot load leaving out at 1350fps.
So as mentioned above you need to determine YOUR criteria, and match it with what you can or wish to accomplish. What you will likely find is that your handguns are far more capable of delivering accuracy than you are. I know mine will shoot better than I can for sure. I am definitely the week link in the chain.