With a semi-auto, you'll not likely see much difference in elevation with different powder charges, assuming they are functioning the action.
With a revolver, (fixed breach), you can increase bullet weight/decrease velocity to increase the barrel lift prior to bullet exiting the muzzle, giving an increase in elevation, or, going to a lighter/faster bullet to lower the impact..
However, with a semi-auto, the bullet exits the barrel before the slide starts to move (casued intentionally by delay in unlocking of barrel through design), such that increases in velocity and bullet weight make little difference. (as contrasted to "NO" difference).
Such is why most semi-autos, aside from those intended for competition aren't equiped with adjustable sights.....
I've had to either lightly file down the front or rear sights to correct an elevation problem with fixed sighted semi-autos..... The latest one, a Springfield XD "Compact" in 9mm.
It shot high at 25yds. I lowered the rear sight and brought it to zero.... But I'm told that you can now get different highth front and rear sights from Springfield to correct this issue.
I too would suggest that you shoot the gun a bit before messing with the sights.
Also, how you grip the gun makes a substantial difference in how it will shoot.
I see some of the most atrocious grip/stances at a public range I frequent. Often a shooter will ask me why they can't "hit". I show them the correct grip/stance and they start hitting, till of course they revert to the way "they want" to shoot... Then they start to miss again and can't understand why.......
Remember; shooting a handgun it's: 1. Grip; 2. Sight alignment; 3. Trigger-squeeze
You can be "dipping" the front of the gun as you fire, causing the gun to shoot low....
focus on the front sight, and once you start the trigger squeze, follow though with it till firing.... If you try to "trigger off" the shot, you will "pull" the shot every time....