I reload .30-06 and .243 on a 550B.
You do have to lube, but the main differences I've read about are whether you trim each time or not.
Some trim below normal "trim-to" length and trim before resizing after the cases get long enough to warrant it.
I don't like this myself, but I'm not saying it is wrong. Just different.
I also don't mess with the dies in the toolhead. They're set and I like to leave them that way.
All you have to do is remove the case after resizing/depriming/repriming. Use the press like it's a single stage. The wire "finger" may have to be adjusted, but it can hold the case during resizing and still permit easy removal.
Then, after checking case length, clean off any excess lube, trim those cases that need it (and chamfer), and then resume progressive operations.
Because you don't want to resize again, just insert a case and index before pulling the handle so that you skip Station 1. (Station 2, 3 and 4 work as usual.)
Hints:
1. If you're loading cases with small neck diameters, excess lube can cause powder bridging at the case mouth. Powder does not enter the case, but it does a dandy job of messing up the press. You can load some reasonable grain sizes, but not if the neck isn't clean and dry.
2. Depending on the volume you load, you may want a powered trimmer. I like the Giraud because it does trim and chamfer simultaneously. Incredibly fast, and easy to change between calibers. (It handles any bottleneck cartridge, but due to the design indexing on the shoulder, it won't handle straight-walled cartridges like .45-70 or .444 Marlin.)