I tried several compensators including one by (I think) Jim Clark, the Wilson Accucomp, and some others, back when I was an active competition shooter (IPSC and USPSA). I also was allowed to try the original Clark Pin-Gun (for bowling pin matches). The pingun didn't have a port and was essentially a weighted extension of the barrel and slide. Yes, they all "worked" in that they did reduce muzzle flip. The problem with their use on a 45, if it is a problem, is that the 45acp is a relatively low-pressure round. They work (the ported models) on the basis that the pressure behind the bullet will be ejected upward, thereby reducing muzzle flip, and to a noticable degree, do. However, they are MUCH MORE effective on the higher pressure rounds like the 38 Super that is "hotted up" enough to make Major caliber in competition.
With that being said, I chose not to equip my 1911 with one because doing so would automaticly take me out of the Limited Class, and put me in with the 'big boys' shooting the high pressure raceguns in the Open/Unlimited Class, where I'd be at even more of a disadvantage. If you are or want to be a competitor in open class, I'd be looking at smaller, higher pressure calibers. I've been out of it so long now that I don't know the current calibers of choice.
Now, assuming that you already have a 45 and aren't going to be competeing, there are some practical aspects you might find that would argue against adding a compensator to your pistol.
1 The availability of finding a suitable holster for your needs.
2 If this is to be a defence gun, and you shoot it in low light, the resulting (depending on your load) muzzle flash WILL blind you.
3 If you shoot at an indoor or covered range and someone hasn't been there before you with a compensated pistol, the first time you shoot, the upwardly ejecting gasses are going to dislodge every bit of dust, dirt, bugs etc, and shower it down on you. Promise.
4 Again, if this is to be a self-defence pistol, I would advise against making any modifications to it other than tritium sights, or modifications (if necessary) to make it 100%reliable. Though I don't have any hard facts, after you've used your gun in SD, the attorney for the family of the puke that broke in, is going to try to prove that any mods you made to the gun were done because the factory gun wasn't deadly enough for you, and that you tried to make it even more lethal, etc. For this same reason, never use your own (or anyone else's) reloads as your defence rounds, use factory ammo, and preferably the same brand and type as your local PD or SD is issued (so long as it functions reliably in your gun).
Anyway, these are my thoughts based on my own experiences with compensated pistols. Hope it helps.
I've actually looked at them myself but had more of a question about whether they affect muzzle flip or or reward recoil. It could change the way the gun cycles. 