Swampwolf,
I own several S&W and Colt DA revolvers. as a lefty I can say that reloading them is very easy for a southpaw. All you need do is develop a lefty manual of arms.
I will attempt to describe how I do it, sorry I don't have pictures but it goes something like this:
From a 2 hand hold the left thumb pushes the latch forward (on a S&W. On a Colt I use my 3:00 side of my palm down left index finger as a hook and pull back on the latch) while the right hand grasps the cylinder and pushes it to the open position with right thumb pressure from 3:00 to 9:00.
At the same time the revolver is rotated to point up.
You are now grasping the cylinder through the gate as if it was a shot glass.
Next, with your left hand palm down with all fingers extended form a "V" by holding your thumb out to 3:00. Place the revolver barrel in that "V" and slap down to eject empty brass.
Still holding the revolver by it's cylinder, rotate it forward till it's pointing down. As if you decided not to drink your shot and threw it on floor.
Simultaneously, retrieve your speed loader with your left hand and then guide it in to the cylinder held in your right hand.
Load the cylinder and release the speed loader and with your left hand grasp the grip, twist to 9:00 with the grip and to 3:00 with the cylinder till it locks and resume your firing grip.
Like anything else, it reads much more complicated that it is
This works for me, YMMV