You know what I'd like to see? I would absolutely love it if Smith or Ruger would design a modern day full size break top revolver. Keep some of the mordern day improved ergonomics, but also retain some of the older styling and nostalgia in those old Iver Johnsons and S&W's.
Then, using modern day metalurgy and science, actually chamber them for common calibers like 38 special, 45 colt, 44 special. I know the reason those older break tops were chambered for less powerful cartridges was due to the inherant weakness of the break top frame, and metalurgy was not what it is today. I should think that with Rugers reputation for overbuilding stuff they could build one in 357 magnum as well. But I'd still go for one in a less powerful cartridge.
I wonder if the fear that someone will put Buffalo Bore or other hot loaded ammo through them and end up blowing them up is why no one has done it. I would think they would sell alright. Hell even paying a high price for a Smith and making it a Performance Center would be alright with me.