I've been reloading for my hunting rifles for several decades and have tried various set ups as a result.
So my own personal recipe hunting set up is Leupold glass with a duplex reticle. I've made a number of shots out as far as 600+ with the duplex reticle. It's really just a matter of what works best for you. A budget Leupold 3x9x40, which is good quality glass, can have the reticle switched out by Leupold for a reasonable fee. They will also make any other up grades as per your desire.
I load a lot of .270 win and 7mm RM, and much like you I like high velocity bullets with reasonably good BC. The 25-06 is a very good cartridge in my opinion, and with the right bullet should make a decent 500 yd. hunting rifle for deer and antelope hutning.
Some critics think I use too light of bullets for the broad range of animals I hunt, but I've never had problems dropping elk with 130 gr. Speer Hot Core @ 3200 fps MV form the .270 win.. For the 7 mag. I go 140 gr. to 145 gr. standard bullets and a MV of around 3250 - 3300 fps.. This has produced some very good long distance performance, but, the Barns line of bullets which gets me down to a 120 gr. BT all copper, offers a little more. The 120 gr. is longer than a conventional jacketed bullet of the same weight, therefore BC is much improved as is MV which is right around 3500 fps.
So far as the ballistic plex, I have used those type of reticles over the years and granted, they do work, they are only as reliable as the testig time you put into determining where POI is at this or that range. But I started tracking my MOA adjustments at various ranges with various bullets at various velocities. This worked quite well and was a about 95% reliable. So a couple of years ago I bought a Leupold RX-IV B&C edition range finder. This sucker ranges out to 1500 yds. and delivers a spot on reliable MOA compensation needed at the turret. It has various TBR (True Ballistic Range) programs to use. So when I range my animal, it displays the precise or near precise MOA adjustment needed at the turret. You simply pick the program that corresponds to your exterior ballistics, velocity, BC, and whether it was zeroed at 100, 200, or 300 yds.. Actually it will indicate what the true zero is for that particular load. For instance, if I'm shooting a bullet with a MV of 3500 fps with a BC of .47 true zero may be 341 yds..