Yep. I carry my KP 345 quite a bit. It is, of course, easier in the winter when heavy outer garments make OWB concealment more feasible. It's a light gun, relatively slim and, when coupled with a quality high-ride leather holster, pretty easy to make disappear.
I got the KP 345 "PR", with the picatinny rail. Haven't gotten around to finding a light for it yet.
The gun's functioning has been absolutely, 100%, guaranteed flawless. No failures to feed, eject, nothing of the sort. Aside from my handloaded 230 FMJ's and lead round nose, I've shot factory 230 fmj's from Magtech, Winchester, Wolf (steel-cased), and American Eagle and never, repeat never, have had a problem with one single round.
Here's a brief range report, with photos, that I did shortly after buying the gun.
http://thehighroad.org/showthread.php?t=118219&highlight=ruger+345+range+report
It's a breeze to field strip and clean, has good sights, good ergonomics...
I think you'd like this gun.