I mainly use Unique in 38/357/44s/44m/45acp/45C. Some in 9mm, very seldom but some in 30-30, 30-06, and 45-70 with cast bullets. I don't worry about .3 grain variation in the bigger cases. Heck, I'm not good enough to tell the difference on target. With small stuff, 380, 9mm, 38 sp. I use a Redding or RCBS, both the same, drum type measure and it holds .1 grain accuracy. I weigh quite often, however.
BTW, I LOVE Unique. The name says it all. Or, you can be good at something but not good at everything...take your choice. It is great for some things, good for others and unsuitable for other things. I think great in handguns. I don't personally care one way or the other about "dirty".