Wow, lots of input! Didn't have much of a chance to check this thread over the weekend. A while ago my wife has fondled a Kahr P40 and wasn't too enthused with it (couldn't shoot it, just hold). There was a S&W that she did seem to like at the same gun show that we saw the Kahr, though I can't remember which one it was. She doesn't like the look of the Glocks, and though she really hasn't handled them, the Glock trigger turns her off. Can't say I'm a huge fan of Glocks myself, though I've only put 5 rounds through one (a guy at the range with one recognized me from church that morning and let me try it). From what she's said I think an autoloader is what she really wants (something about "I don't want a revolver").
I'll have her check out the P232/239, and the Ladysmith (auto and wheel), plus the SP101, though I doubt she'll go for the revolvers as noted above. Most of the list from mr_dove will also be explored.