I just don't think you can beat a .243, or a .270 for an all around shooter. My wife busts 350# mule deer with her .243, while I just lean on the .270 for 99% of my shooting needs. If elk is in your future, you may lean towards the 30-06, but a .270 is an acceptable round for elk. Anything bigger, go bigger. IMHO, you just can't do it all with one gun, depending on your needs, things will change.