Colt did invent a revolveing rifle/carbine in 1855 ..it wasn`t built on his pistol frame , his revolving rifle/carbine ...was large caliber and the weapon had a top strap over the cylinder it shot lead round balls .
Do you really want to build a carbine on the Walker frame with a wedge holding the barrel in place and shoot heavy bullets .
Colts open top design works pretty well for loose powder and round balls , but even with the use of a 45 Lc conversion cylinder you are takeing a chance on shooting the barrel loose shooting heavy bullets .
Then there is always the where the heck do you put your off hand .......its only natural to go for the forearm hold .......and that can be a very bad place with such a weapon ..