I once had a Safari in .338 win mag with the BOSS muzzle brake on it... plenty accurate, kinda heavy, amazingly loud. Definitely did more than touch a few deer with it and all of them went down pretty quickly... anywhere from down at the place of impact to as far away as probably 40 yards or so.
Ultimately, when a .300 Wby Mark V came home to roost, the Browning went away. Nothing wrong with it, it just quit getting used and looked lonely in the back of the safe.
Really no down side to owning one that I can think of.