N-frames will handle stout .357 loads. As with any gun, maximum loads, maximize wear and tear.
N-frames soak up recoil pretty well, too. Recoil is a very personal thing, though.
I love the .357 but, grizzly is a little outside of it's "weight class." Sure, it can be done but...
Usually .44 mag is considered the ante, to sit at the table with a grizzly.
Of course most any handgun is outclassed by grizzly. And most any gun is better than no gun.
Also not to be overlooked, the ubiquitous "...two-legged predators, more likely than..." comment.