So aside from tha treble we might get into if our bass ain't right...what I have found is the best bullets are square and flat based with no tear out from the sprue cut.
I shoot an awful lot of cast handgun bullet at longer ranges simple due to practice makes perfect. That said I'm hunting with these out to around 50yds. Not spectacular but nonetheless I want to know that a load groups tight at 75 - 100yds so I reduce the adrenaline factor at 50 or less. Those bullets with a divit or tear in the base are usually outliers in the group. They are used for practice purposes only. For hunting purposes I will scrutinize a poured batch in order to get the best weight and sized tolerance before loading.
For rifle, I've noticed that some tiny imperfections to the driving bands may or may not show influence, but I always toss those with something showing on the base or bottom band. The other thing I have found is when using a GC, if it isn't seated square, it ain't gonna shoot to group. This is usually the result of the exiting gas influencing the bullet as it leaves the barrel.