I like to get a good compromise of both. However, if i can only have one or the other, like you, i want penetration (hence my use of Buff.Bore hard cast flat nose in my P32)
I'm definitely going to get some of the Buff.Bore hard cast flat nose for my .380 too, for trail hiking and such. I spend some time up my uncles place up the mountains, there are some critters up there that would not be impressed in the slightest with .380 JHPs.
However, here in the city, the nasties i face will be of the 2 legged variety, and - most likely- i will be faced with a frontal engagement. In such an engagement, 10% of penetration is more than enough, even against a jolly old fat guy.
If i find myself facing a situation where i have to make quartering or profile shots, i might regret my choice of DPX, but then, if i do have a frontal engagement, which i again think is the most likely scenario, i want the 100% expansion the Corbon DPX .380 has demonstrated that it's capable of in gel testing, because 10" pen. will be plenty in that scenario.
And honestly, i think the DPX's copper cutting petals will do a heck of a lot of damage in their own right.
But it's all a compromise. Like all things in life.