Thats how I shoot when I'm only using one hand. Of course, I'm cross-dominate and it works for me.A slight cant in your wrist can make a one-handed hold more comfortable, but not any more than 30 degrees from upright.
To get my sights back on target quickly, I was taught to hold my gun at ~15 degree angle inward when shooting single-handed. Works great. Try it sometime. The degree of cant varies per shooter. I found 15 reliable. Others may need more or less.A slight cant in your wrist can make a one-handed hold more comfortable, but not any more than 30 degrees from upright.