I'm one of those +40 responders.When I started rifle hunting in the 1970s I "harvested" at least 50 Alabama whitetails with a .243, all inside 200 yards, and only lost one. He dropped like a sack, I walked up to him, noticed a crease on the neck, tried to figure out how that could be fatal, reached over and touched the deer's eye with the muzzle, he jumped up flailing hooves and covered 100 yards of broomsage in about 2 heartbeats. Nowadays I use a 270, and have taken over 200 deer with it. I just feel a little more confident with it on long shots. I also learned to take shoulder shots. We have lots of deer in Alabama, so a wasted shoulder is a lesser evil than an entire unrecovered animal.