I'll be completely honest with you:
If you're looking for a serious home defense gun, do not get a gun that is a rifle action configured as a pistol.
Guns like the Draco or the Olympic Arms OA93 basically combine the worst aspects of a rifle with the worst aspects of a handgun.
They're larger and bulkier than a handgun, which means they require more strength to hold and aim properly. Additionally the lack of a shoulder stock means that they are going to be harder to aim than a rifle.
Also, the very short barrels on these guns tends to result in a gun that is exceedingly loud with a very prominent muzzle flash, both things that will hinder you if you find yourself having to defend your home at 3:30 AM.
For home defense, you'd be best going with a shotgun with a proper shoulder stock, or a handgun like a Glock, S&W M&P, or SIG.
For the most part, unless you have a physical disability of some sort, a long gun shouldn't be too hard to handle, especially for something like a home defense scenario.
Either way, a shotgun or handgun would be a much more practical choice for home defense than something like a Draco.
If you don't have much pre-existing experience shooting firearms, I'd also recommend taking an introductory self-defense or firearms safety course.