I am coming in late, and haven't read the entire thread, but here are a few thoughts on the Ruger 10/22:
My 10/22 has been very reliable, more reliable than most .22LRs, but not 100%. I didn't keep a round count, but I have undoubtedly put in excess of 100,000 rounds through it in the last decade and a half, and have only
needed to replace the extractor (Volquartsen makes a great replacement). I kept the rifle stock for many years, but decided to modify it into a target rifle a few years back, in doing so I replaced the stock, the bolt release (a great mod., that allows the bolt to close by pulling the charging handle back), and the barrel. IMO that is the best use for the 10/22, someone that wants a semi-auto custom target rifle.
Parts are very available. It is the Rem. 700 or AR-15 of the custom .22lr market. Modifications are exceptionally simple, no gunsmithing, and little tools are required for most modifications. Most operations are performed by just unbolting and unbolting the part.
If you are not looking for a custom rifle, to modify with aftermarket parts, and quite frankly spend more than the value of the rifle on, the 10/22 may not be the rifle for you. IMO the Marlin M-60 is a better value, and every one that I have shot, has performed better than a 10/22 out of the box. To achieve a comparable accuracy level, you will have to spend a good bit more on the 10/22, which is already a more expensive rifle without modification. That said, if you do it right, the 10/22 can easily outshoot the Marlin, it all depends upon what you want to spend to get there.
The new ones may be just as strong, and just as good, but I don't like em'. It is one thing to have Al. parts on a rifle, but something completely different when you start replacing parts on a traditionally styled rifle with plastic. I like my old model, and if I were to look for a replacement I would search for a model with the original Al. parts and anodized receiver (current model is painted instead).