So my question at this point seems like it should be 45acp v 357mag.
For a first gun, considering that it will be for the backcountry & that you have large hands, I'd recommend a .357 magnum. Here's my reasoning:
- it's easier to learn to use a revolver
- while .357 magnum & .45 acp get about the same performance, .357 gets better penetration, which is important for protection from wild animals
- it's very easy to add a revolver grip that will fit your hands, while autos usually leave you with fewer choices
Hunters prefer revolvers because reliability is of utmost importance, either for animal protection or for hunting. You want to be absolutely, positively
sure that the gun will fire, and while new Glocks have an excellent reputation in this regard, I'd still put more trust in a revolver.
I'd say that autos withstand abuse better than revolvers, but revolvers can better withstand neglect. In my opinion, both modern autos or revolvers do pretty well in both departments, but each has its edge over the other.
For woods carry with a .357, I'd recommend a 4-6" barrel. 4" will capture most of the ammo's performance, but 6" will be easier to aim and might get you a couple hundred extra fps. Look for 180 to 200 grain hardcast ammo instead of lighter expanding ammo; a heavy, solid bullet will usually penetrate better. At the range, I mostly shoot lightweight .38 special hollowpoints. Shooting the hard stuff all the time gives me a flinch.
Both Ruger and S&W make excellent .357's. Rugers are a little heavier & tougher, while Smiths usually have a smoother trigger out of the box.
If I had my heart set on carrying a .45 auto for the woods, I'd choose a new model with the longest barrel I could find and load it with +p hardcast ammo.