I went through a similar thought process recently. I actually already had a 45ACP wheelgun; I am a big fan of the 45, found a nice S&W M22, and bought it. I don't shoot it much, though. I find I like the 45ACP through a 1911 much more; the recoil of the M22 is a little much with the slim stock wood grips. I'd probably like it more with some better hand-filling grips, but I can't bring myself to swap out those pretty wood stocks, so it just sits in the safe save a few range trips a year.
Anyway.. I decided I wanted a 357 or 44. I reload now, as well, and figured I could deal with either calibre. I went scouring the local gun shops, and a 4" S&W M27 in nickel grabbed me and asked to come home. So the 357 it was...
Boy am I happy I grabbed that gun! It has the same frame/stocks as my M22 but it's much more pleasant to shoot. And since I reload I can shoot anything from a mouse fart 38spl. wadcutter to a ridiculously boomy and fire-spitting 357. All are fun, out of that gun! And as a reloader, I can load up 38's for around $3.50 a box of 50... Nice. 357's are more, but still less than 9mm factory ammo. What a superbly versatile gun. 44 mag is also quite versatile, but everything about it is more expensive; brass, primers, powder (more of it), and bullets...
I don't hunt much, but have friends who do. I live in OH, and they all claim a 357 is as much as you need here. 357 should do you just fine in our neck of the woods...
THAT SAID... I'd still like a 44. I do travel to big bear country once a year, and if carry is allowed in national parks, I sure would like a 44 on the hip. But in OH? If I go hunting with my buddies, I think I might pick up a 6+" 357...
HTH, YMMV.