I keep a GP-100 with a 6" barrel for home defense duty.
I chose one of two loads:
Federal 125 grain semi-jacketed hollow point .357 Magnum (left in picture)- the legendary "357B" load that gave the .357 magnum is near mythic reputation of neutralizing the threat with extreme prejudice.
Propels it's SJHP bullet at about 1600 fps from a 6" bbl creating roughly 700 ft lbs. of muzzle energy. Creates massive wound trauma through hyper-expansion and fragmentation of the exposed lead hollowpoint, while the tougher jacketed base of the bullet continues to penetrate deep to reach vital organs. Usually expends all energy in the target in the form of a huge permanent wound cavity, leading to massive hemorrhaging and the rapid drop in blood pressure needed to incapacitate an aggressor if a CNS shot is not achieved. A classic load that has stood the test of time and perhaps is the single most effective loading in the single most effective handgun caliber suitable for self defense ever made. It will do the job.
I also like to use the Speer Gold-Dot 125 grain JHP .357 Magnum load (right in picture), and I'll explain why. It too delivers it's bullet at about 1600 fps from a 6" barrel for 700 ft lbs of energy, but can have some advantages over the older Federal load.
While the famous Federal 357B load is tremendously effective, in some situations it's SJHP design does not lend itself to maximum performance when intermediate barriers are presented between the target and the shooter. While delivering high terminal performance in living tissue, the Federal semi-jacketed bullet can fail when it is fired through cover such as automobile glass, sheet metal, wood and dwelling walls. This is due to the exposed soft lead hollowpoint and non-bonded design of the bullet.
With the Speer Gold-Dot .357 magnum 125 grain load, a specially designed fully jacketed hollow point bullet is used that can effectively defeat barriers and still deliver good terminal performance inside the target. It does this by using what's know as a "bonded bullet", this is where the copper outer jacket is chemically and physically bonded with the lead core. What this does is create a tough bullet that will expand very consistently under many circumstances, but that will hold together when encountering barriers. This makes the Speer Gold Dot loads so popular with Law Enforcement personnel, who may need to shoot through cover provided by automobiles and structures in order to eliminate a hostile.
So in closing, it's very difficult to go wrong with either of these loads for home defense. Depending on your situation/the time of year, etc. they both complement each other in there capabilities and provide excellent stopping power.
Pick your poison.