S & W
I frame = Slightly smaller predecessor to the more modern J frame.
J frame = 5-shot .38 special, .357, and .32's, with some in .22 LR.
K frame is the most common S&W, the old-standby Model 10 M&P, Model 19 Combat Magnum, etc..
L frame is fairly new (1980s) and is a heavier size for .357 guns that are shot a lot with heavy loads, also a .44 special.
M frame = Tiny size used only for the 7 shot .22 Ladysmith revolver of the early 20th century.
N frame is the big .44 special, .44 mag, .45 Colt,.45 ACP and the big frame .357.
X frame .460 S&W mag, .500 S&W mag.
Colt:
P frame = Single Action Army (cowboy gun)
G, K, and Q = various models of the .22 LR in SAA style
F frame = Black-powder guns (they call all of the guns an F frame even though there are some size differences)
D Frame = Detective Special
E Frame = Officer's Model Match, Official Police and Trooper (original version) Firing pin in hammer.
I Frame (Python) = Same size as E, except firing pin in frame.
J Frame = Official Police Mk III, Trooper Mk III and V, King Cobra, various variants of these.
O Frame = 1911 Automatic
S Frame = Colt Woodsman .22 Auto (and various match grade versions of same)
rc