It doesn't take a lot of muzzle velocity to poke a hole in a target at 25 yards. One of the joys of shooting cast bullets is that they lend themselves to mild loads that are fun to shoot.
One thing to watch is that if you get too mild, you won't have enough spin to stabilize the bullet and your accuracy will suffer. If you're too hot, you can get leading near the muzzle, and your accuracy will suffer again. In the Goldilocks zone there is a lot of room and many loads that will work well.
My wife and both my daughters have 2" 38s, the latter two being ultralight. For those, I load 124 grain cowboy action bullets (very much on the light side) at about 750 FPS. Those are great plinking cartridges, and the ladies enjoy them. Those stabilize and are accurate.
You might find a lot of good choices in the Cowboy Action section of some of the online reloading manuals.
Many powders are position sensitive with reduced loads. That is, you'll get very different results if you lower you muzzle into position vs. if you raise it into position. Two powders that I have found that are not position sensitive are TiteGroup and Universal.