I am just a heavy bullet kinda guy. I run 200 gr XTPs from Grizzly Cartridge Co for defense and hunting use, and a 200 gr FMJ handloaded to similar velocities (~1200 fps from a 4.6 inch KKM in a Gen III G20) for practice and woods carry.
I was debating with a friend whether the 10mm Auto could do everything the .45 ACP can do better than the .45 ACP, and he brought up the use of sound suppressors. The .45 ACP being low pressure and subsonic makes it a pretty good suppressor host, so I began questioning what I would use if I was suppressing a 10mm Auto. With velocity pegged at no more than about 1000 fps, it makes sense to use the heaviest bullet possible. So while a 200 gr could be loaded to .40 S&W velocities and still serve functionally as a suppressed round, a 220 gr bullet loaded to the same velocity would obviously be better. The round would still be higher pressure than the .45, and therefore not a quiet, but all things considered, a 220 gr .40 caliber round at 1000 fps is probably going to be at least as effective as a 230 gr .45 cal round at 850 fps.
Then I began questioning whether, having obtained a supply of non-expanding 220 gr projectiles, it wouldn't be prudent to find a full power load pushing this at or above 1100 fps for service in bear country. That would obviously depend on how hard the bullet was and a bunch of other factors that would be brought up in testing.
Anyways, thanks for the input!