I agree that you are looking at this in a good way, and your choices make sense. I also wish Colt still made the Python.
If it were ME, I would remember that if this is a defensive gun for indoor use, a .357 is about the loudest possible choice. Tinitis is better than death, but I'm also a guitar player, and I might find myself wondering after the fact if there was a way to do the job with less hearing damage. If you're a revolver guy, that's fine, I would get out and shoot as many of the popular brands as possible, but I would also try some of the obvious auto choices. You might find you like them too. If this is strictly a home gun, I would get the heaviest and longest practical option. (full-size auto, 6-8 inch barrel revolver.) Heavier guns have less felt recoil, and longer guns are easier to fire accurately.