What an interesting list of possibilities we have assembled. What I take to be the OP's quest is something like a MKIII, but with a bit more beef to the grip.
If that's the case a Ruger 22/45 would certainly do, as would a S&W 22A.
My personal favorites are a Mitchell Trophy (I didn't stay away from them), a Savage Striker (not exactly a pistol), and mostly my Dan Wesson.
But asking which pistol is best is kinda like asking what girl is the prettiest. You're gonna get alot of different answers, some of which may not make any sense to you.
BTW, Jeanine Garofalo, see I told you some of them wouldn't make any sense.