For home defends a wheelgun is best. It's called simplicity. You can used it with one hand. You don't worry about mags, racking slides.& is there a round in the chamber.
It may be best for your situation, but I agree with others in this thread that you'd probably be faster and more accurate with any shoulder fired weapon.
You or your spouse can use it without to much training.
Without much training, my spouse learned to operate and hit what she was aiming at very easily with both shotguns and rifles. It took her a lot more time and training to get proficient, even at fairly close ranges, to hit where she wanted to with a handgun.
My experience mirrors hers, although mine isn't a good comparison because I grew up shooting shotguns and rifles. She started everything at the same time and picked up long guns much more easily.
Try to wake up 1 or 2 in the morning and grab your ak, ar, sks,fal,or shotgun and know where your family is and where the would be assailant is when you start shooting with your asault rifle and bullets are going through walls.
As for the first part, the confusion and knowing where your family and the assailant are would apply to any platform of firearm. They don't magically go away with a revolver.
As for the second part, as has been mentioned multiple times in this thread, handgun rounds also penetrate walls, and generally retain more energy after passing through the assailant and walls than HD purpose designed 5.56.
You do not want a round to fragment, weight retention is best as it enables greater penetration in vitals.
And through vitals, and through backs, and through drywall, and through the neighbor's drywall, etc. A major point of this thread is that in home defense you need to get to the vital organs while hopefully controlling the leftover energy after the round reaches the vitals. A bullet breaking apart is a method of attempting to achieve this.