I have a degree of contempt for the gun magazines telling us repeatedly that a full-size pistol can't be carried. When they do, there's usually a compact pistol on the cover.
It's like car magazines trying to convince you you need three different jeeps to do different things in life. The rule for guns should be the same as jeeps. If you can afford it, go for it. But they all have four wheels.
But I'm superstitious. Especially when I'm hanging my life on the object of superstition. I don't want three different pistols, holsters, triggers, sights, weights, recoils etc kicking around in my brain. I don't want to have to test three different pistols for ammo and reliability. When I have one that works, I will keep it and use it for everything.
It makes me think of the scene in "Dirty Rotten Scoundrels" when Michael Caine is walking Steve Martin through the wine cellar, explaining, "This is the best wine in the world." "Great. Drink it." "Oh, no, I can't drink it, it's far to valuable." "Ok, sell it." "I can't sell it, it means far too much to me." I honestly would feel foolish, having a rookie look in my safe, and having him ask me, "But aren't all three of those pistols pretty much the same? Why do you have three of them?" As far as I'm concerned, the only correct response to that question is; "Because I can afford them and I like them." Not "I need three different guns to do the same thing under three different sets of circumstances."
I have one great full-size 1911. I carry it every day, I wear it when in the wilderness, and I will take it with me to war, even if that means leaving it there to avoid customs trouble. It is the pistol that fits me best and does what I tell it to every time.
Comfort is relative. If you aren't used to carrying, a sub-compact....anything will be uncomfortable. If you are a 21 year-old kid with a rambo fetish, a .50 Desert Eagle will make you feel warm and fuzzy under your left armpit. Detemine which pistol fits you and your circumstances best, carry it, and bite the bullet. So to speak. And remember, a longer barrel means better muzzle velocity and sight radius.
I forgot to answer the question, I use a Galco Miami Classic, a fanny pack, and a cheap nylon IWB. (I want to get a Milt Sparks.)