I've been reloading for the 38/357 for several months now and no failures with over 2,000 rounds. I've bee reloading for my son's 9mm for 2 weeks and no failures there either with 500 rounds. All went bang and no FTF or FTE problems either. I've used FMJ and LRN in the 9mm too. Just make sure your load isn't too light and pay close attention to the OAL and you will be fine.
You are totally correct, buying 5,000 rounds of .45 ACP will cost you a lot of $$, making them will save you plenty. Even on sale buying bulk I bet 5,000 factory rounds will cost you well over $1,500.00. I bet you can make them for under $700 if you already have enough brass.