My system is to check the reliability of the gun, check the reliability of the gun/ammo combination, the type of lube and cleaning method, the holster and spare ammo carrier, and HOW I personally carry the gun and magazines.
First, I fire at least 200 rounds of cheaper ammo through the gun to break it in and turn up any possible defects in the gun.
After a through cleaning of the gun AND magazines, I'll fire at least 100 rounds of the defense ammo to check reliability and targeting.
This 100 rounds I fire in as many ways as possible, and without cleaning or re-lubing.
I fire slow fire, rapid fire, and with the gun in odd positions.
I always start each magazine off with the magazine fully loaded, a round in the chamber, and the gun in whatever condition it'll be carried in (cocked and locked, double action, etc).
The gun must fire ALL the verification rounds with ZERO failures of any kind.
Once the gun has handled the 100 round proof test, I again give the gun and magazines a thorough cleaning and lube.
I load it up and carry it and the spare magazines for several weeks, WITHOUT unloading, lubing or otherwise disturbing the gun OR magazines.
Then, just as I would in a real defense situation, I draw and shoot the gun empty, reload with the spare magazines and shoot them to check for any problems that might show up from having been carried.
While I check my defense gun EVERY DAY, this test will show up any problems caused by dust or dirt from carrying, degraded lube, ammo shifting in the magazines, or problems cause by the carry method.
As an example, lubes can evaporate, run off, wick off, or gum up.
Ammo in the magazines or in the gun can shift the top round into a position that might cause jams, OR in some cases, ammo can actually work it's way out of the spare magazines.
I once had a magazine pouch that after being carried for a long day, when the magazine was removed, there was a loose round in the bottom that movement had pushed out of the mag.