It depends a lot on the cartridge, whether for rifle or pistol, and your reloading habits.
In general;
If you load hot all the time, brass will not last as long.
If you full length resize all the time (for rifle), case life will usually be limited by how long the case head stays attached to the rest of the case. A factor in this situation will be the size of the chamber in the rifle. Working your brass from its actual fire formed size back to SAAMI specs with every load will stretch the case just ahead of the web, and the case will fail, sometimes after only a few reloads.
If you primarily neck size rifle brass, it should last longer if you also take the time to anneal the necks. You are still probably going to have to bump back the shoulder now and then to get it to chamber. If you don't anneal, some brass will fail from split case necks fairly early. Maybe 4-5 rounds. Sometimes more. It's hard to predict. Annealing brass that has been properly sized for the chamber of the rifle can double case life if neck sizing.
For straight walled pistol brass, case life is usually dictated by neck splits, and sometimes split case walls. If you get really long life from your brass without neck splits, you will likely eventually end with cases that will not hold a primer. After many firings primer pockets stretch.
How many loads can you get safely? Well, it depends on what cartridge, and how you load it. A few examples from my own experience:
I have 38 Special brass that is heading upwards of 20 reloads. They are practice loads, and I throw them away when the neck splits or the primers start going in too easy.
I get 10-15 loads from my 45 ACP brass. Then neck splits.
22 Hornet, about 10 loads. I can just start to feel a head separation ring about that time, and I chuck them.
30-06 in a Garand, about 5-6 loads. After that many FL re-sizings a ring will make itself evident near the case head, and out it goes. You have to watch for this with most autoloading rifles.
Bolt rifles will end up with head separations too, but you can fine tune your sizing to limit it to some extent.
You will have to decide for yourself, really. Guns are individuals when it comes to chambers, and that has a lot to do with brass life.