I would visually inspect each bolt notch on the cylinder for edge wear and general buggering. The edges should be straight, vertical, with minimal if any wear. A slight ring is normal on Rugers. Making sure the gun is empty, allow the hammer to drop from full cock and while holding the trigger all the way back try to wiggle the cylinder front and back and side to side. A Ruger is not going to lock up like a Python, but there should be very little play front to back or side to side. The ratchet teeth on the cylinder should not be worn or buggered. The end of the hand should not be worn or buggered. The visible part of the bolt protruding from the frame when the cylinder is removed should not be worn or buggered. The base pin should be a mirror for its whole length. The trigger should be reasonably crisp, not like a Colt or Smith and Wesson, but liveable and not gritty or stagey. The slot in the frame into which the hammer fits should have clean smooth edges without damage, and there should not be severe wear on the side of the hammer.
The good news is, its a Ruger. If something is amiss, return it to the factory and they will take excellent care of you.