Quarterbore Is Better
A longtime friend had a .22-250 that he bought for target and woodchucks. When he burned out the barrel shooting target, he sold it. I pesonally had a passion from about age 14 for a .257 Roberts, and in 1982 I found a new tang safety Ruger on the rack at my LGS in Mass. I love my .257 Bob, and it is my go-to gun for deer. I recently dialed in a good load with Nosler 115gr. Ballistic tips, and the last group I shot with it had a max. spread of 0.322" at 100 yds. (in heavy rain, with a gusting crosswind, and yeah- in those conditions it was a pleasant surprise!). But the .257 Bob is unfortunately "obsolete," and for brass the last time I needed it, I ended up buying some 7x57 and necking it down to .257 - it was good enough for Ned Roberts, so I guess it's good enough for me.
The .257 has needed some "tuning" after installation of a Timney trigger, but its record for whitetails is 6 for 6, all DRT. Now, I would not recommend a Roberts because it is a reload only cartridge, and brass is scarce. But I definitely see either a .243 or a .257 caliber as the best choices.
As for northeast short range deer shots, that's generally true, BUT my last one here in the NY Catskills showed up 200 yds away in a recently cut hayfield; no chance to stalk closer, so one shot across the field.