As much as I love the ROA, wouldn't it get a bit heavy for daily carry?
If I wanted the most powerful, reliable, could drive fenceposts with it and not hurt it durable, then I'd have to go with the ROA.
If I was going to use it for self protection from humans who wish to do me ill, the LeMat is the best choice, by far, with it's 9 shots of .44 and 1 shot of 20 ga.
If I needed one that was a good compromise between the two, I'd go with my Remington New Army(incorrectly called an 1858, the Italian reproductions are actually the 1863 model. I'll be glad to elaborate, if requested)
If I purely wanted the most effective hunting and 4 legged critter self protection pistol, it sure as hell wouldn't be any revolver. It would be my Pedersoli 20 gauge Howdah pistol. Shoot one and you'll understand. It hits,HARD!
350 grain roundballs backed up with 50-60 grains of fffg will take care of any close encounter of the tough, ornery critter kind you'll have on this continent, far better than 6 rounds from Any .44 BP revolver.
Plus, birdshot and buckshot can be used for hunting birds, small game, and close range deer.
Detractors, go ahead and flame away. I stand by my decision. There's much more to the Howdah than ballistically meets the eye. Being a smoothbore, you can shoot soft lead, wheelweights (either as-cast or heat treated), #2 , or linoype balls through it to suit your penetration/expansion needs.
Buy one, I guarantee you'll be as giddy as a schoolgirl after you drop the hammer the first time.