Each new cartridge would have to be evaluated individually. Some cartridges take off while most get ignored. Look at 10MM which quickly led to .40 S&W. 10MM floundered for quite a while and .40 took off. Now .40 is losing favor because many agencies are reverting to 9MM. However 10MM is more popular than ever and there are new guns coming out on a regular basis chambered for this round.
I wouldn’t be surprised if .327 Federal takes off but I also wouldn’t be surprised if it remains a niche caliber or dies off. The caliber fills a void between .22 lr and .38/.357, however one could make the argument that between high velocity .22’s, target .38 loads, or up to full strength .357’s there’s not a lot of room for a new caliber to make headway. A couple dozen people on firearm forums can be all for a new caliber and debate how wonderful it will be but that doesn’t necessarily translate into many firearms being sold.
The problem that any new caliber runs into is that we’ve pretty much got the full spectrum of power well covered at this point. People experiment and come up with more powerful versions of existing rounds regularly but the general public typically ignores them i.e. 9x21, 9x23, 9x25, etc.
Then you got the big boys i.e 454 Casull, 460 and 500 S&W, 480 Ruger which are basically limited in appeal to a few small niches. I’d like to pick up a 460 S&W but realistically my .44 Mag 29-2 can do anything I would ever need a big bore handgun to do.