Most of the time, .1 or .2gr will not make much difference. in other words, if you CAREFULLY, with a good scale, load a series to be fired, say, 5-10rounds, the variation from high to low, will be more than the variation from the test load to the next heavier/lighter test load if the weight difference is held to .1-.2gr.
I've had quite a few shooters tell me they can tell the difference between two rounds that were loaded .2-.5gr apart, by just shooting them. POPPYCOCK!!!
Why are there pressure guns, and chronographs? I'm sure someone will tell me that it's to quantify, and that's true, but it's also to compare.
If you are loading to a point that .2 will make a difference from a KB, I don't want to be anywhere near you!!!
Semi-autos, especially handguns, have a narrow window of pressures/velocities so that loading hot, or max, doesn't get advantagious. Max, for an auto, means that more will cause unnecessary wear. Why beat the gun up for no real improvement? If you want that .45 Auto be be THAT much hotter, trade it for a .45 WinMag. Autos can be tuned for different ranges of pressures, ie light target, or +P, but even THAT window is small.
I can get my .45 to reliably shoot 230gr at 650-700fps, or 900fps, but what's the advantage? of the 900fps-er, anyway?
Some confuse "dirty" with seeing a few kernals of semi-burned powder in the bore.It's blown out of the barrel by the next bullet before the next bullet gets to the 'kernal.' 'Dirty' is found by running a tight, cloth patch down the tube, and two different powders MAY be difficult to quantify.
Unique is a little more erratic to measure than U.Clays, but not so much that it is a real problem. The only thing you can do is practice and get it right. What you might do is to prep say....1000cases, and start loading by measuring the powder into the scale before loading. You'll do whatever is necessary to get it to drop right! I've overstated the case, but my point is...just practice.
Why do I think I'm right? A chronograph, and a LOT of ammo!
Have fun,
Gene