Since I own one, maybe I can give some insight, I'm right handed and righ eye dominant, but I can shot left handed very well (long story).
The disconnector release button can easily be engaged by the lefty's trigger finger.
The ejector port is far enough forward as not to cause a problem there.
Only the safety would be backwards and I believe there's aftermarket kits that would fix that.
fawndog if you install a m4 recoil pad the recoil will be tamed.