Yes, yes, yes! By all means, shoot BP in your Uberti; I do mine. I will agree with most of what has been written here, and in particular with J.W.
Buy soft bullets that are lubed with a soft, gooey, BP lube. Don't shoot hard bullets or hard, waxy lube. It is just more hassle. 255 grain bullet will work nicely to start off with, and the Colt traditional bullet is a RN with a small meplat. You can load hollow-based bullets, if you can find or cast them, but flat-based bullets are fine if sized correctly. I always order or size to 0.454" for any .45 Colt cartridge. The over-sized bullet does no harm in any gun. Try
www.cowboybullets.com for starters; I've had good luck with them.
Shoot either FFg or FFFg or mix them to make 2&1/2Fg. I experimented with this and FFg is fine, but velocity is low. FFFg is fine, but fouls heavily. The Frankford Arsenal used a powder that approximated 2&1/2Fg. That works great and the fouling is less than with FFFg. Goex is fine, Swiss is better. A 30 to 35 grain load is fine, and less is OK as long as the case is filled. I shoot 20 grains with grits as a filler lots of times. There is no real need for a card wad in the pistol cases. Get a powder compression die from
www.buffaloarms.com. You will need it sooner or later. You can stuff 40 grains of powder in a case with a compression die, but 40 grains is a real stout load. It's a hoot! Winchester cases are preferred because of their thinner walls and resultant larger capacity. However, Starline work well, they're just a little harder to get a bit load into.
I like WW large pistol primers. They are a little hotter than some of the rest (WW primers are hotter to compensate for WW ball powders).
A good, tight crimp is best, so use the Lee Factory Carbide crimp die. Besides, it will resize your cases on the way back out of the die and all your ammo will chamber properly.
My Uberti is an old Cimarron and has 0.458" cylinder throats. I ordered a special mould that casts 0.458" bullets and ordered a special sizing die and a Lee Carbide Factory crimp die to properly load the bigger bullets. I works great.
Beware of the static electricity warnings: The jury is still out on this one. I'll agree that it is not as big a problem as once was thought, but someone just brought out a rifle that uses an electronic ignition system,
a la spark plug or something like that. Until I find out how they are doing that, I will still be at least cautious around BP.