Here's a post from a man who knows what he's talking about. (Thanks HSMITH)
Lenny, I assume this is for 45 acp.....
Here is the secret you can't tell anyone else. Really, you have to protect the innocent. Put a round of factory ball in the shell holder/plate. Back your seater way out, back your crimp die way out. Raise the ram all the way, making sure while you are going up that it isn't going to touch the dies.
Now, if you seat and crimp in one step, you have to screw the die body down making sure the seater doesn't touch. Just screw the die body down finger tight, lower the ram and give it 1/16th of a turn more down and lock it. Raise the ram again and screw the seater down finger tight against the bullet, lock it. Load one round of the new load without powder or primer, measure and compare the OAL of the round you loaded to the book. If you are short of book drop your starting load a little, if you are long start just above starting loads.
If you seat and crimp in two dies just seperate the steps above.
Set your 45 dies this way and your guns will feed just about any bullet you can find. Accuracy improvements with OAL changes in a handgun are nothing like rifles, get a decent load that functions every time and leave it alone.